GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedge...
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
About this item
Full title
Author / Creator
Hoppe, Nicholas , Harrison, Simone , Hwang, Sun-Hee , Chen, Ziwei , Karelina, Masha , Deshpande, Ishan , Suomivuori, Carl-Mikael , Palicharla, Vivek R. , Berry, Samuel P. , Tschaikner, Philipp , Regele, Dominik , Covey, Douglas F. , Stefan, Eduard , Marks, Debora S. , Reiter, Jeremy F. , Dror, Ron O. , Evers, Alex S. , Mukhopadhyay, Saikat and Manglik, Aashish
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in development by suppressing Hedgehog signaling. The fundamental basis of how GPR161 is activated remains unclear. Here, we determined a cryogenic-electron microscopy structure of active human GPR161 bound to heterotrimeric G
s
. This structure revealed an extracellular...
Alternative Titles
Full title
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
Authors, Artists and Contributors
Author / Creator
Harrison, Simone
Hwang, Sun-Hee
Chen, Ziwei
Karelina, Masha
Deshpande, Ishan
Suomivuori, Carl-Mikael
Palicharla, Vivek R.
Berry, Samuel P.
Tschaikner, Philipp
Regele, Dominik
Covey, Douglas F.
Stefan, Eduard
Marks, Debora S.
Reiter, Jeremy F.
Dror, Ron O.
Evers, Alex S.
Mukhopadhyay, Saikat
Manglik, Aashish
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11221913
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11221913
Other Identifiers
ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/s41594-024-01223-8
