Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Simple, efficient and well-tolerated delivery of CRISPR genome editing systems into primary cells remains a major challenge. Here we describe an engineered Peptide-Assisted Genome Editing (PAGE) CRISPR–Cas system for rapid and robust editing of primary cells with minimal toxicity. The PAGE system requires only a 30-min incubation with a cell-penetr...
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Full title
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11230135
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11230135
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ISSN
1087-0156,1546-1696
E-ISSN
1546-1696
DOI
10.1038/s41587-023-01756-1
