Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy
Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy
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United States: John Wiley and Sons Inc
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Language
English
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Publisher
United States: John Wiley and Sons Inc
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INTRODUCTION
A noncoding variant (rs35349669) within INPP5D, a lipid and protein phosphatase restricted to microglia in the brain, is linked to increased susceptibility to Alzheimer's disease (AD). While Inpp5d is well‐studied in amyloid pathology, its role in tau pathology remains unclear.
METHODS
PS19 Tauopathy mice were crossed with Inp...
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Full title
Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11247686
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11247686
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ISSN
1552-5260,1552-5279
E-ISSN
1552-5279
DOI
10.1002/alz.14078
