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The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anti...

The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anti...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11251483

The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases

About this item

Full title

The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases

Publisher

Cham: Springer International Publishing

Journal title

Journal of computer-aided molecular design, 2023-12, Vol.37 (12), p.755-764

Language

English

Formats

Publication information

Publisher

Cham: Springer International Publishing

More information

Scope and Contents

Contents

Owing to their potential to cause serious adverse health effects, significant efforts have been made to develop antidotes for organophosphate (OP) anticholinesterases, such as nerve agents. To be optimally effective, antidotes must not only reactivate inhibited target enzymes, but also have the ability to cross the blood–brain barrier (BBB). Progre...

Alternative Titles

Full title

The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11251483

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11251483

Other Identifiers

ISSN

0920-654X,1573-4951

E-ISSN

1573-4951

DOI

10.1007/s10822-023-00537-x

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