PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis
PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis
About this item
Full title
Author / Creator
Yamaguchi, Junna , Isnard, Pierre , Robil, Noémie , de la Grange, Pierre , Hoguin, Clément , Schmitt, Alain , Hummel, Aurélie , Megret, Jérôme , Goudin, Nicolas , Luka, Marine , Ménager, Mickaël M. , Masson, Cécile , Zarhrate, Mohammed , Bôle-Feysot, Christine , Janiszewska, Michalina , Polyak, Kornelia , Dairou, Julien , Baldassari, Sara , Baulac, Stéphanie , Broissand, Christine , Legendre, Christophe , Terzi, Fabiola and Canaud, Guillaume
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Proliferative glomerulonephritis is a severe condition often leading to kidney failure. There is a significant lack of effective treatment for these disorders. Here, following the identification of a somatic PIK3CA gain-of-function mutation in podocytes of a patient, we demonstrate using multiple genetically engineered mouse models, single-cell RNA...
Alternative Titles
Full title
PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis
Authors, Artists and Contributors
Author / Creator
Isnard, Pierre
Robil, Noémie
de la Grange, Pierre
Hoguin, Clément
Schmitt, Alain
Hummel, Aurélie
Megret, Jérôme
Goudin, Nicolas
Luka, Marine
Ménager, Mickaël M.
Masson, Cécile
Zarhrate, Mohammed
Bôle-Feysot, Christine
Janiszewska, Michalina
Polyak, Kornelia
Dairou, Julien
Baldassari, Sara
Baulac, Stéphanie
Broissand, Christine
Legendre, Christophe
Terzi, Fabiola
Canaud, Guillaume
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11290976
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11290976
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI176402
