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Androgen aggravates aortic aneurysms via suppression of PD-1 in mice

Androgen aggravates aortic aneurysms via suppression of PD-1 in mice

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11290977

Androgen aggravates aortic aneurysms via suppression of PD-1 in mice

About this item

Full title

Androgen aggravates aortic aneurysms via suppression of PD-1 in mice

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2024-08, Vol.134 (15), p.1-20

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Androgen has long been recognized for its pivotal role in the sexual dimorphism of cardiovascular diseases, including aortic aneurysms (AAs), a devastating vascular disease with a higher prevalence and fatality rate in men than in women. However, the mechanism by which androgen mediates AAs is largely unknown. Here, we found that male, not female,...

Alternative Titles

Full title

Androgen aggravates aortic aneurysms via suppression of PD-1 in mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11290977

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11290977

Other Identifiers

ISSN

1558-8238,0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI169085

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