Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
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Publisher
Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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Contents
Geldanamycin, an
-macrolide composed of a rigid benzoquinone ring and an aliphatic
-bridge, was isolated from
. Geldanamycin is a potent heat shock protein inhibitor with remarkable antiproliferative activity. However, it shows pronounced hepatotoxicity in animal models and unfavorable pharmacokinetic properties. Four geldanamycin analogs...
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Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11509085
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11509085
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms252011293
