Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced...
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
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Author / Creator
Shao, Wenkai , Wang, Bo , Wang, Ping , Zhang, Shuo , Gong, Song , Guo, Xiaodong , Duan, Deyu , Shao, Zengwu , Liu, Weijian , He, Lei , Gao, Fei , Lv, Xiao and Feng, Yong
Publisher
China: Springer Nature B.V
Journal title
Language
English
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Publication information
Publisher
China: Springer Nature B.V
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Contents
Osteonecrosis of the femoral head (ONFH) is a common complication of glucocorticoid (GC) therapy. Recent advances demonstrate that sympathetic nerves regulate bone homeostasis, and GCs lower the sympathetic tone. Here, we show that the dramatically decreased sympathetic tone is closely associated with the pathogenesis of GC-induced ONFH. GCs activa...
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Full title
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549335
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549335
Other Identifiers
ISSN
2095-4700
E-ISSN
2095-6231
DOI
10.1038/s41413-024-00371-3
