Molecular and In Silico Analysis of the CHEK2 Gene in Individuals with High Risk of Cancer Predispos...
Molecular and In Silico Analysis of the CHEK2 Gene in Individuals with High Risk of Cancer Predisposition from Türkiye
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Author / Creator
Ozdemir, Ozkan , Bychkovsky, Brittany L. , Unal, Busra , Onder, Gizem , Amanvermez, Ufuk , Aydin, Eylul , Ergun, Berk , Sahin, Ilayda , Gokbayrak, Merve , Ugurtas, Cansu , Koroglu, Merve Nur , Cakir, Berfin , Kalay, Irem , Cine, Naci , Ozbek, Ugur , Rana, Huma Q. , Hatirnaz Ng, Ozden and Agaoglu, Nihat Bugra
Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
Background and Objectives: Checkpoint kinase 2 (CHEK2) is a tumor suppressor gene involved in DNA repair and cell cycle regulation. Pathogenic or likely pathogenic (P/LP) variants in CHEK2 are associated with increased cancer risk. Conversely, recent large cohort studies have identified certain variants that, despite being classified as P/LP by in...
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Full title
Molecular and In Silico Analysis of the CHEK2 Gene in Individuals with High Risk of Cancer Predisposition from Türkiye
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11592704
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11592704
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ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers16223876
