Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
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Author / Creator
Tsai, Chih-Ming , Hajam, Irshad A. , Caldera, J.R. , Chiang, Austin W.T. , Gonzalez, Cesia , Du , Choudhruy, Biswa , Li, Haining , Suzuki, Emi , Askarian, Fatemeh , Clark, Ty’Tianna , Lin, Brian , Wierzbicki, Igor H. , Riestra, Angelica M. , Conrad, Douglas J. , Gonzalez, David J. , Nizet, Victor , Lewis, Nathan E. and Liu, George Y.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that IL-10 is the decisive factor that abrogates antibody protection in mice. Sa-induced B10 cells drive antigen-sp...
Alternative Titles
Full title
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11645145
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11645145
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI179563
