P2RX7 deficiency prevents cognitive deficit, brain atrophy and tauopathy progression in PS19 mice vi...
P2RX7 deficiency prevents cognitive deficit, brain atrophy and tauopathy progression in PS19 mice via suppression of extracellular vesicle secretion and mitochondrial toxicity
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Publisher
Hoboken: John Wiley and Sons Inc
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Language
English
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Publisher
Hoboken: John Wiley and Sons Inc
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Background
We previously identified the novel mechanism of pathological tau transfer via extracellular vesicles (EVs) in Alzheimer’s disease (AD). Targeting EV secretion to mitigate tau transfer is therefore a promising therapeutic approach for AD. P2X purinoreceptor 7 (P2RX7), an ATP‐gated cationic channel, regulates microvesicle shedding or se...
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Full title
P2RX7 deficiency prevents cognitive deficit, brain atrophy and tauopathy progression in PS19 mice via suppression of extracellular vesicle secretion and mitochondrial toxicity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709570
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709570
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ISSN
1552-5260
E-ISSN
1552-5279
DOI
10.1002/alz.088010
