Cellular overexpression of mutant TDP‐43 results in a decrease in solubility of phosphorylated TDP‐4...
Cellular overexpression of mutant TDP‐43 results in a decrease in solubility of phosphorylated TDP‐43
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Publisher
Hoboken: John Wiley and Sons Inc
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Language
English
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Publisher
Hoboken: John Wiley and Sons Inc
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Background
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that is characterized by upper and lower motor neuron death that leads to paralysis with the average survival being 3‐5 years after diagnosis. The major pathological protein in ALS is TDP‐43. TDP‐43 becomes hyperphosphorylated and forms inclusions mainly in...
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Full title
Cellular overexpression of mutant TDP‐43 results in a decrease in solubility of phosphorylated TDP‐43
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709745
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709745
Other Identifiers
ISSN
1552-5260
E-ISSN
1552-5279
DOI
10.1002/alz.090006
