APOE4 Drives Liver/Brain Proteomic Shifts in Young Mice and Alters Metabolic Function Across iPSC‐De...
APOE4 Drives Liver/Brain Proteomic Shifts in Young Mice and Alters Metabolic Function Across iPSC‐Derived Hepatic and Neuronal Cells
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Hoboken: John Wiley and Sons Inc
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English
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Hoboken: John Wiley and Sons Inc
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Background
Altered liver function and dysregulated metabolism are emerging risk factors for Alzheimer’s disease (AD). This includes genetic variation in apolipoprotein E (APOE), which is the strongest genetic risk determinant for AD. APOE is highly secreted by hepatocytes in the liver and astrocytes in the brain and plays a significant role in l...
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APOE4 Drives Liver/Brain Proteomic Shifts in Young Mice and Alters Metabolic Function Across iPSC‐Derived Hepatic and Neuronal Cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11710498
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11710498
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ISSN
1552-5260
E-ISSN
1552-5279
DOI
10.1002/alz.092482
