Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expre...
Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells
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Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
United States: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
G-quadruplexes (G4s) are four-stranded alternative secondary structures formed by guanine-rich nucleic acids and are prevalent across the human genome. G4s are enzymatically resolved using specialized helicases. Previous
studies showed that DEAH-box Helicase 36 (DHX36/G4R1/RHAU), has the highest specificity and affinity for G4 structures. Here,...
Alternative Titles
Full title
Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11722296
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11722296
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2025.01.03.631217
