cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans
About this item
Full title
Author / Creator
Patel, Dinshaw J. , Yu, You and Xie, Wei
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The metazoan cGAMP-activated cGAS–STING innate immunity pathway is triggered in response to genomic instability and DNA damage, thereby providing host defense against microbial pathogens. This pathway also impacts on autophagy, cellular senescence and antitumor immunity, while its overactivation triggers autoimmune and inflammatory diseases. Metazo...
Alternative Titles
Full title
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans
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Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11749898
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11749898
Other Identifiers
ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/s41594-023-00933-9
