Rescue of hippocampal synaptic plasticity and memory performance by Fingolimod (FTY720) in APP/PS1 m...
Rescue of hippocampal synaptic plasticity and memory performance by Fingolimod (FTY720) in APP/PS1 model of Alzheimer's disease is accompanied by correction in metabolism of sphingolipids, polyamines, and phospholipid saturation composition
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United States: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
United States: Cold Spring Harbor Laboratory Press
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Previously, our metabolomic, transcriptomic, and genomic studies characterized the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease, and we demonstrated that FTY720, a sphingosine-1-phospahate receptor modulator approved for treatment of multiple sclerosis, recovers synaptic plasticity and memory in APP/PS1 mice. To fur...
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Full title
Rescue of hippocampal synaptic plasticity and memory performance by Fingolimod (FTY720) in APP/PS1 model of Alzheimer's disease is accompanied by correction in metabolism of sphingolipids, polyamines, and phospholipid saturation composition
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11761635
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11761635
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ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2025.01.17.633452
