HMGA1 acts as an epigenetic gatekeeper of ASCL2 and Wnt signaling during colon tumorigenesis
HMGA1 acts as an epigenetic gatekeeper of ASCL2 and Wnt signaling during colon tumorigenesis
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Author / Creator
Luo, Li Z. , Kim, Jung-Hyun , Herrera, Iliana , Wu, Shaoguang , Wu, Xinqun , Park, Seong-Sik , Cho, Juyoung , Cope, Leslie , Xian, Lingling , West, Bailey E. , Calderon-Espinosa, Julian , Kim, Joseph , Thompson, Zanshé , Maloo, Isha , Larman, Tatianna , Reddy, Karen L. , Feng, Ying , Fearon, Eric R. , Sears, Cynthia L. and Resar, Linda
Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Mutated tumor cells undergo changes in chromatin accessibility and gene expression, resulting in aberrant proliferation and differentiation, although how this occurs is unclear. HMGA1 chromatin regulators are abundant in stem cells and oncogenic in diverse tissues; however, their role in colon tumorigenesis is only beginning to emerge. Here, we unc...
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Full title
HMGA1 acts as an epigenetic gatekeeper of ASCL2 and Wnt signaling during colon tumorigenesis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11785931
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11785931
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI184442
