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Cellular and molecular features of asthma mucus plugs provide clues about their formation and persis...

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persis...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11910225

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence

About this item

Full title

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2025-03, Vol.135 (6), p.1-16

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

BACKGROUNDMucus plugs form in acute asthma and persist in chronic disease. Although eosinophils are implicated in mechanisms of mucus pathology, many mechanistic details about mucus plug formation and persistence in asthma are unknown.METHODSUsing histology and spatial, single-cell proteomics, we characterized mucus-plugged airways from nontranspla...

Alternative Titles

Full title

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11910225

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11910225

Other Identifiers

ISSN

1558-8238,0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI186889

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