Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems
Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems
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Author / Creator
Bobonis, Jacob , Mitosch, Karin , Mateus, André , Karcher, Nicolai , Kritikos, George , Selkrig, Joel , Zietek, Matylda , Monzon, Vivian , Pfalz, Birgit , Garcia-Santamarina, Sarela , Galardini, Marco , Sueki, Anna , Kobayashi, Callie , Stein, Frank , Bateman, Alex , Zeller, Georg , Savitski, Mikhail M. , Elfenbein, Johanna R. , Andrews-Polymenis, Helene L. and Typas, Athanasios
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Retrons are prokaryotic genetic retroelements encoding a reverse transcriptase that produces multi-copy single-stranded DNA
1
(msDNA). Despite decades of research on the biosynthesis of msDNA
2
, the function and physiological roles of retrons have remained unknown. Here we show that Retron-Sen2 of
Salmonella enterica
serovar Typh...
Alternative Titles
Full title
Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems
Authors, Artists and Contributors
Author / Creator
Mitosch, Karin
Mateus, André
Karcher, Nicolai
Kritikos, George
Selkrig, Joel
Zietek, Matylda
Monzon, Vivian
Pfalz, Birgit
Garcia-Santamarina, Sarela
Galardini, Marco
Sueki, Anna
Kobayashi, Callie
Stein, Frank
Bateman, Alex
Zeller, Georg
Savitski, Mikhail M.
Elfenbein, Johanna R.
Andrews-Polymenis, Helene L.
Typas, Athanasios
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11938430
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11938430
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-05091-4
