Impaired ketogenesis in Leydig Cells drives testicular aging
Impaired ketogenesis in Leydig Cells drives testicular aging
About this item
Full title
Author / Creator
Liu, Congyuan , Peng, Hao , Yu, Jiajie , Luo, Peng , Xiong, Chuanfeng , Chen, Hong , Fan, Hang , Ma, Yuanchen , Ou, Wangsheng , Zhang, Suyuan , Yang, Cuifeng , Zhao, Lerong , Zhang, Yuchen , Guo, Xiaolu , Ke, Qiong , Wang, Tao , Deng, Chunhua , Li, Weiqiang , Xiang, Andy Peng and Xia, Kai
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, we show that Leydig cells are particularly vulnerable to aging processes in testis. Single-cell RNA sequencing identifies the expression of
Hmgcs2
, the gene encoding rate-limiting enzyme of ketogenesis,...
Alternative Titles
Full title
Impaired ketogenesis in Leydig Cells drives testicular aging
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12056170
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12056170
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-59591-8
