Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation
About this item
Full title
Author / Creator
Kimman, Thomas , Cuenca, Marta , Tieland, Ralph G. , Rockx-Brouwer, Dedeke , Janssen, Jasmijn , Motais, Benjamin , Slomp, Anne , Pleijte, Corine , Heijhuurs, Sabine , Meringa, Angelo D. , Boschloo, Wendy , Bosma, Douwe MT , Kroos, Sanne , lo Presti, Vania , Sluijter, Joost P. G. , Nierkens, Stefan , Bovenschen, Niels , Kuball, Jürgen , van Mil, Alain , Minnema, Monique C. , Sebestyén, Zsolt and Peperzak, Victor
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Clinical responses with chimeric antigen receptor (CAR) T cells are encouraging, but primary resistance and relapse after therapy prevent durable remission in many patients with cancer, with apoptosis resistance in cancer cells that limits killing by CAR T cells being a potential cause. Here we aim to boost tumor cell apoptosis induced by CAR T cel...
Alternative Titles
Full title
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation
Authors, Artists and Contributors
Author / Creator
Cuenca, Marta
Tieland, Ralph G.
Rockx-Brouwer, Dedeke
Janssen, Jasmijn
Motais, Benjamin
Slomp, Anne
Pleijte, Corine
Heijhuurs, Sabine
Meringa, Angelo D.
Boschloo, Wendy
Bosma, Douwe MT
Kroos, Sanne
lo Presti, Vania
Sluijter, Joost P. G.
Nierkens, Stefan
Bovenschen, Niels
Kuball, Jürgen
van Mil, Alain
Minnema, Monique C.
Sebestyén, Zsolt
Peperzak, Victor
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12089368
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12089368
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-59818-8
