A murine model of Barth syndrome recapitulates human cardiac and skeletal muscle phenotypes
A murine model of Barth syndrome recapitulates human cardiac and skeletal muscle phenotypes
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Publisher
England: The Company of Biologists
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Language
English
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Publisher
England: The Company of Biologists
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Scope and Contents
Contents
Barth syndrome is a mitochondrial disorder with hallmarks of cardiac and skeletal muscle weakness. It is caused by pathogenic variants in the X-linked gene tafazzin (TAZ), required for cardiolipin remodeling. Previously described germline and conditional Taz knockout models are not ideal for therapeutic development because they lack the combination...
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Full title
A murine model of Barth syndrome recapitulates human cardiac and skeletal muscle phenotypes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12128220
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12128220
Other Identifiers
ISSN
1754-8403
E-ISSN
1754-8411
DOI
10.1242/dmm.052077
