Idarucizumab more effectively reverses the anticoagulant effects of dabigatran acylglucuronide than...
Idarucizumab more effectively reverses the anticoagulant effects of dabigatran acylglucuronide than dabigatran
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Dabigatran acylglucuronide, an active metabolite of dabigatran, exhibits higher plasma concentrations and distinct anticoagulant effects compared to dabigatran, suggesting that it may play a more significant role in overall anticoagulant activity than previously assumed. Idarucizumab, a monoclonal antibody fragment, binds to both free and thrombin-...
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Full title
Idarucizumab more effectively reverses the anticoagulant effects of dabigatran acylglucuronide than dabigatran
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12214677
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_12214677
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-025-08417-0
