Rapid Directional Shift of Mitochondrial DNA Heteroplasmy in Animal Tissues by a Mitochondrially Tar...
Rapid Directional Shift of Mitochondrial DNA Heteroplasmy in Animal Tissues by a Mitochondrially Targeted Restriction Endonuclease
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Frequently, mtDNA with pathogenic mutations coexist with wild-type genomes (mtDNA heteroplasmy). Mitochondrial dysfunction and disease ensue only when the proportion of mutated mtDNAs is high, thus a reduction in this proportion should provide an effective therapy for these disorders. We developed a system to decrease specific mtDNA haplotypes by e...
Alternative Titles
Full title
Rapid Directional Shift of Mitochondrial DNA Heteroplasmy in Animal Tissues by a Mitochondrially Targeted Restriction Endonuclease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1242285
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1242285
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0502896102
