Ebselen: A Substrate for Human Thioredoxin Reductase Strongly Stimulating Its Hydroperoxide Reductas...
Ebselen: A Substrate for Human Thioredoxin Reductase Strongly Stimulating Its Hydroperoxide Reductase Activity and a Superfast Thioredoxin Oxidant
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one], a seleno-organic compound with glutathione peroxidase-like activity is used in clinical trials against stroke. Human and bovine TrxR catalyzed the reduction of ebselen to ebselen selenol by NADPH with an apparent KM-value of 2.5 µM and a kcatof 588 min-1. The addition of thioredoxin (Trx) stimulate...
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Full title
Ebselen: A Substrate for Human Thioredoxin Reductase Strongly Stimulating Its Hydroperoxide Reductase Activity and a Superfast Thioredoxin Oxidant
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_124318
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_124318
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.122061399
