Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and prom...
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
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Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Chichester, UK: John Wiley & Sons, Ltd
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Activation of proMMP‐2 by MT1‐MMP is considered to be a critical event in cancer cell invasion. In the activation step, TIMP‐2 bound to MT1‐MMP on the cell surface acts as a receptor for proMMP‐2. Subsequently, adjacent TIMP‐2‐free MT1‐MMP activates the proMMP‐2 in the ternary complex. In this study, we demonstrate that MT1‐MMP forms a homophilic c...
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Full title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_125610
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_125610
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ISSN
0261-4189,1460-2075
E-ISSN
1460-2075
DOI
10.1093/emboj/20.17.4782
