Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-inde...
Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
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United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by Staphylococcus aureus that has recently been associated with necrotizing pneumonia. In the present study, we report that in vitro, PVL induces polymorphonuclear cell death by necrosis or by apoptosis, depending on the PVL concentration. PVL-induced apoptosis was associated with a...
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Full title
Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1265849
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1265849
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ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI22684
