Y586F Mutation in Murine Leukemia Virus Reverse Transcriptase Decreases Fidelity of DNA Synthesis in...
Y586F Mutation in Murine Leukemia Virus Reverse Transcriptase Decreases Fidelity of DNA Synthesis in Regions Associated with Adenine-Thymine Tracts
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Using in vivo fidelity assays in which bacterial β-galactosidase or green fluorescent protein genes served as reporters of mutations, we have identified a murine leukemia virus (MLV) RNase H mutant (Y586F) that exhibited an increase in the retroviral mutation rate ≈5-fold in a single replication cycle. DNA-sequencing analysis indicated that the Y58...
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Full title
Y586F Mutation in Murine Leukemia Virus Reverse Transcriptase Decreases Fidelity of DNA Synthesis in Regions Associated with Adenine-Thymine Tracts
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_126629
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_126629
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.152186199
