ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
The p53 tumor suppressor is activated after DNA damage to maintain genomic stability and prevent transformation. Rapid activation of p53 by ionizing radiation is dependent on signaling by the ATM kinase. MDM2 and MDMX are important p53 regulators and logical targets for stress signals. We found that DNA damage induces ATM‐dependent phosphorylation...
Alternative Titles
Full title
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1276172
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1276172
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7600812
