WNK3 Kinase Is a Positive Regulator of NKCC2 and NCC, Renal$Cation-Cl^-$Cotransporters Required for...
WNK3 Kinase Is a Positive Regulator of NKCC2 and NCC, Renal$Cation-Cl^-$Cotransporters Required for Normal Blood Pressure Homeostasis
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
WNK1 and WNK4 [WNK, with no lysine (K)] are serine-threonine kinases that function as molecular switches, eliciting coordinated effects on diverse ion transport pathways to maintain homeostasis during physiological perturbation. Gain-of-function mutations in either of these genes cause an inherited syndrome featuring hypertension and hyperkalemia d...
Alternative Titles
Full title
WNK3 Kinase Is a Positive Regulator of NKCC2 and NCC, Renal$Cation-Cl^-$Cotransporters Required for Normal Blood Pressure Homeostasis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1283841
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1283841
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0508303102
