Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase e...
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
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Author / Creator
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
Edema factor (EF) and CyaA are calmodulin (CaM)‐activated adenylyl cyclase exotoxins involved in the pathogenesis of anthrax and whooping cough, respectively. Using spectroscopic, enzyme kinetic and surface plasmon resonance spectroscopy analyses, we show that low Ca
2+
concentrations increase the affinity of CaM for EF and CyaA causing their...
Alternative Titles
Full title
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_139101
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_139101
Other Identifiers
ISSN
0261-4189,1460-2075
E-ISSN
1460-2075
DOI
10.1093/emboj/cdf681
