Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
The MDM2 homolog MDMX is an important regulator of p53 during mouse embryonic development. DNA damage promotes MDMX phosphorylation, nuclear translocation, and degradation by MDM2. Here we show that MDMX copurifies with 14‐3‐3, and DNA damage stimulates MDMX binding to 14‐3‐3. Chk2‐mediated phosphorylation of MDMX on S367 is important for stimulati...
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Full title
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1422166
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1422166
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7601032
