An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
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Author / Creator
Boeddrich, Annett , Gaumer, Sébastien , Haacke, Annette , Tzvetkov, Nikolay , Albrecht, Mario , Evert, Bernd O , Müller, Eva C , Lurz, Rudi , Breuer, Peter , Schugardt, Nancy , Plaßmann, Stephanie , Xu, Kexiang , Warrick, John M , Suopanki, Jaana , Wüllner, Ullrich , Frank, Ronald , Hartl, Ulrich F , Bonini, Nancy M and Wanker, Erich E
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
Arginine/lysine‐rich motifs typically function as targeting signals for the translocation of proteins to the nucleus. Here, we demonstrate that such a motif consisting of four basic amino acids in the polyglutamine protein ataxin‐3 (Atx‐3) serves as a recognition site for the interaction with the molecular chaperone VCP. Through this interaction, V...
Alternative Titles
Full title
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1440312
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1440312
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7601043
