Spinal Cord Endoplasmic Reticulum Stress Associated with a Microsomal Accumulation of Mutant Superox...
Spinal Cord Endoplasmic Reticulum Stress Associated with a Microsomal Accumulation of Mutant Superoxide Dismutase-1 in an ALS Model
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Mutation in superoxide dismutase-1 (SOD1), which is a cause of ALS, alters the folding patterns of this protein. Accumulation of misfolded mutant SOD1 might activate endoplasmic reticulum (ER) stress pathways. Here we show that transgenic mice expressing ALS-linked SOD1 mutants exhibit molecular alterations indicative of a recruitment of ER's signa...
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Full title
Spinal Cord Endoplasmic Reticulum Stress Associated with a Microsomal Accumulation of Mutant Superoxide Dismutase-1 in an ALS Model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1458691
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1458691
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0509227103
