Spatiotemporal Control of Spindle Midzone Formation by PRC1 in Human Cells
Spatiotemporal Control of Spindle Midzone Formation by PRC1 in Human Cells
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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We have examined the role of PRC1, a midzone-associated, microtubule bundling, Cdk substrate protein, in regulating the spatiotemporal formation of the midzone in HeLa cells. Cdk-mediated phosphorylation of PRC1 in early mitosis holds PRC1 in an inactive monomeric state. During the metaphase-to-anaphase transition, PRC1 is dephosphorylated, promoti...
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Full title
Spatiotemporal Control of Spindle Midzone Formation by PRC1 in Human Cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1458854
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1458854
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0506926103
