Lack of IL-15 Results in the Suboptimal Priming of CD4⁺ T Cell Response against an Intracellular Par...
Lack of IL-15 Results in the Suboptimal Priming of CD4⁺ T Cell Response against an Intracellular Parasite
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
IFN-γ-producing CD4⁺ T cells, although important for protection against acute Toxoplasma gondii infection, can cause gut pathology, which may prove to be detrimental for host survival. Here we show that mice lacking IL-15 gene develop a down-regulated IFN-※-producing CD4⁺ T cell response against the parasite, which leads to a reduction in gut necro...
Alternative Titles
Full title
Lack of IL-15 Results in the Suboptimal Priming of CD4⁺ T Cell Response against an Intracellular Parasite
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1458934
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1458934
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0506180103
