PKCε Increases Endothelin Converting Enzyme Activity and Reduces Amyloid Plaque Pathology in Transge...
PKCε Increases Endothelin Converting Enzyme Activity and Reduces Amyloid Plaque Pathology in Transgenic Mice
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Publisher
National Academy of Sciences
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Language
English
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Publisher
National Academy of Sciences
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Contents
Deposition of plaques containing amyloid P3 (AP3) peptides is a neuropathological hallmark of Alzheimer's disease (AD). Here we demonstrate that neuronal overexpression of the ε isozyme of PKC decreases Aβ levels, plaque burden, and plaque-associated neuritic dystrophy and reactive astrocytosis in transgenic mice expressing familial AD-mutant forms...
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Full title
PKCε Increases Endothelin Converting Enzyme Activity and Reduces Amyloid Plaque Pathology in Transgenic Mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1472455
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1472455
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0509725103
