Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Single-Channel Gating by Bivalent...
Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Single-Channel Gating by Bivalent PDZ-Domain-Mediated Interaction
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent protein kinase- and ATP-regulated chloride channel, the activity of which determines the rate of electrolyte and fluid transport in a variety of epithelial tissues. Here we describe a mechanism that regulates CFTR channel activity, which is mediated by PDZ domains, a...
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Full title
Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Single-Channel Gating by Bivalent PDZ-Domain-Mediated Interaction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_14749
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_14749
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.031538898
