Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
About this item
Full title
Author / Creator
Habashi, Jennifer P , Judge, Daniel P , Holm, Tammy M , Cohn, Ronald D , Loeys, Bart L , Cooper, Timothy K , Myers, Loretha , Klein, Erin C , Liu, Guosheng , Calvi, Carla , Podowski, Megan , Neptune, Enid R , Halushka, Marc K , Bedja, Djahida , Gabrielson, Kathleen , Rifkin, Daniel B , Carta, Luca , Ramirez, Francesco , Huso, David L and Dietz, Harry C
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor-{szligbeta} (TGF-{szligbeta}) family of cytokines. We show that aortic aneurysm in a mouse model of MFS is assoc...
Alternative Titles
Full title
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Authors, Artists and Contributors
Author / Creator
Judge, Daniel P
Holm, Tammy M
Cohn, Ronald D
Loeys, Bart L
Cooper, Timothy K
Myers, Loretha
Klein, Erin C
Liu, Guosheng
Calvi, Carla
Podowski, Megan
Neptune, Enid R
Halushka, Marc K
Bedja, Djahida
Gabrielson, Kathleen
Rifkin, Daniel B
Carta, Luca
Ramirez, Francesco
Huso, David L
Dietz, Harry C
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1482474
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1482474
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1124287
