Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endotheli...
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome
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Author / Creator
Manuelian, T , Hellwage, J , Meri, S , Caprioli, J , Noris, M , Heinen, S , Jozsi, M , Neumann, HPH , Remuzzi, G and Zipfel, P F
Publisher
American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
American Society for Clinical Investigation
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Scope and Contents
Contents
Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Recent studies have identified a factor H-associated form of HUS, caused by gene mutations that cluster in the C-terminal region of the complement regulator factor H. Here we report how three mutations (E1172St...
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Full title
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_152934
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_152934
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI200316651
