Requirement for Metabolic Activation of Acetylaminofluorene to Induce Multidrug Gene Expression
Requirement for Metabolic Activation of Acetylaminofluorene to Induce Multidrug Gene Expression
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Publisher
United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
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Language
English
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Publisher
United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
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Contents
Previously we have demonstrated that several xenobiotics can induce multidrug (mdr) gene expression in cultures of primary isolated hepatocytes. One of the best of these xenobiotic inducers in rat hepatocytes is 2-acetylaminofluorene (2-AAF), which induces mdr expression by an enhancement of mdr gene transcription. In all species studied to date, A...
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Full title
Requirement for Metabolic Activation of Acetylaminofluorene to Induce Multidrug Gene Expression
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Author / Creator
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1566854
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1566854
Other Identifiers
ISSN
0091-6765
E-ISSN
1552-9924
DOI
10.1289/ehp.94102s6209
