Polyclonal Antibodies to Quantitate Cis-Diamminedichloroplatinum(II)-DNA Adducts in Cancer Patients...
Polyclonal Antibodies to Quantitate Cis-Diamminedichloroplatinum(II)-DNA Adducts in Cancer Patients and Animal Models
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Publisher
United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
Journal title
Language
English
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Publication information
Publisher
United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
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Scope and Contents
Contents
cis-Diamminedichloroplatinum (II) (cis-DDP), the antitumor drug, is cytotoxic in vitro primarily by binding to DNA and disrupting its normal functions. We have studied cis-DDP modification of DNA in nucleated peripheral blood cells (buffy coat cells) of testicular and ovarian cancer patients receiving cis-DDP chemotherapy, and of untreated controls...
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Full title
Polyclonal Antibodies to Quantitate Cis-Diamminedichloroplatinum(II)-DNA Adducts in Cancer Patients and Animal Models
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1568668
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1568668
Other Identifiers
ISSN
0091-6765
E-ISSN
1552-9924
DOI
10.1289/ehp.856289
