Arylamine-DNA Adducts in vitro and in vivo: Their Role in Bacterial Mutagenesis and Urinary Bladder...
Arylamine-DNA Adducts in vitro and in vivo: Their Role in Bacterial Mutagenesis and Urinary Bladder Carcinogenesis
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Publisher
United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
Journal title
Language
English
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Publication information
Publisher
United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
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Contents
Hepatic N-oxidation, followed by N-glucuronidation, has been proposed as a route of metabolic activation for arylamine bladder carcinogens. It is postulated that the N-glucuronides are transported to the bladder lumen where they are hydrolyzed under slightly acidic conditions to release direct-acting carcinogenic and mutagenic N-hydroxyarylamines....
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Full title
Arylamine-DNA Adducts in vitro and in vivo: Their Role in Bacterial Mutagenesis and Urinary Bladder Carcinogenesis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1569140
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1569140
Other Identifiers
ISSN
0091-6765
E-ISSN
1552-9924
DOI
10.1289/ehp.8349125
