Comparison of novel cannabinoid partial agonists and SR141716A in the guinea‐pig small intestine
Comparison of novel cannabinoid partial agonists and SR141716A in the guinea‐pig small intestine
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Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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The controversial nature of the CB1 receptor antagonist, SR141716A, in the guinea‐pig small intestine was investigated by comparing it with four analogues of Δ8‐tetrahydrocannabinol (Δ8‐THC): O‐1184, O‐1238, O‐584 and O‐1315.
These compounds (10–1000 nM) inhibited the electrically‐evoked contractions with a rank order of potency of O‐1238>O‐1184...
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Full title
Comparison of novel cannabinoid partial agonists and SR141716A in the guinea‐pig small intestine
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1571886
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1571886
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ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0703094
