Tyr‐c[D‐Orn‐Tyr(Bzl)‐Pro‐Gly]: a novel antiproliferative acting somatostatin receptor agonist with μ...
Tyr‐c[D‐Orn‐Tyr(Bzl)‐Pro‐Gly]: a novel antiproliferative acting somatostatin receptor agonist with μ‐opioid receptor‐sensitizing properties
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Contents
Here, we introduce a β‐casomorphin‐5‐derived cyclic pentapeptide, cCD‐2 (Tyr‐cyclo[D‐Orn‐Tyr(Bzl)‐Pro‐Gly]), which inhibits the cell growth of a variety of human cancer cell lines.
This opioid‐derived peptide possesses only low affinity for μ‐receptors, but enhances the agonist binding to μ‐receptors in vitro and potentiates the analgesic effect...
Alternative Titles
Full title
Tyr‐c[D‐Orn‐Tyr(Bzl)‐Pro‐Gly]: a novel antiproliferative acting somatostatin receptor agonist with μ‐opioid receptor‐sensitizing properties
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1574013
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1574013
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ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0705416
