Simultaneous central nervous system distribution and pharmacokinetic–pharmacodynamic modelling of th...
Simultaneous central nervous system distribution and pharmacokinetic–pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats
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Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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The objective of this study was to investigate the contribution of norfloxacin blood–brain barrier (BBB) transport to its delayed electroencephalogram (EEG) effect in rats.
Norfloxacin was injected as a bolus dose of 150 mg kg−1. Blood samples were collected for total norfloxacin plasma concentration measurements. The corresponding unbound level...
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Full title
Simultaneous central nervous system distribution and pharmacokinetic–pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1574943
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1574943
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ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0705748
