Inhibition of TGF‐β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine‐induced li...
Inhibition of TGF‐β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine‐induced liver fibrosis
About this item
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Publisher
Oxford, UK: Blackwell Publishing Ltd
Journal title
Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Contents
1
Chronic liver disease is characterized by an exacerbated accumulation of matrix, causing progressive fibrosis, which may lead to cirrhosis. Transforming growth factor beta (TGF‐β), a well‐known profibrotic cytokine, transduces its signal through the ALK5 ser/thr kinase receptor, and increases transcription of different genes including PAI‐1 an...
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Full title
Inhibition of TGF‐β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine‐induced liver fibrosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1576127
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1576127
Other Identifiers
ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0706172
