Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colit...
Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis
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Publisher
American Society for Clinical Investigation
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Language
English
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American Society for Clinical Investigation
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Scope and Contents
Contents
Enhanced NF-κB activity is involved in the pathology of both forms of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Here we analyzed the mechanism of proteasome-mediated NF-κB activation in CD and UC. Our studies demonstrate that the subunit composition and the proteolytic function of proteasomes differ between U...
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Full title
Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1654202
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1654202
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI28804
