Voltage-Sensor Sodium Channel Mutations Cause Hypokalemic Periodic Paralysis Type 2 by Enhanced Inac...
Voltage-Sensor Sodium Channel Mutations Cause Hypokalemic Periodic Paralysis Type 2 by Enhanced Inactivation and Reduced Current
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
The pathomechanism of familial hypokalemic periodic paralysis (HypoPP) is a mystery, despite knowledge of the underlying dominant point mutations in the dihydropyridine receptor (DHPR) voltage sensor. In five HypoPP families without DHPR gene defects, we identified two mutations, Arg-672→ His and → Gly, in the voltage sensor of domain 2 of a differ...
Alternative Titles
Full title
Voltage-Sensor Sodium Channel Mutations Cause Hypokalemic Periodic Paralysis Type 2 by Enhanced Inactivation and Reduced Current
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_16902
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_16902
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.97.17.9549
