Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanis...
Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanism
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Scope and Contents
Contents
The surface comparison of different serine-threonine and tyrosine kinases reveals a set of 30 residues whose spatial positions are highly conserved. The comparison between active and inactive conformations identified the residues whose positions are the most sensitive to activation. Based on these results, we propose a model of protein kinase activ...
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Full title
Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1693824
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1693824
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0607656103
